5-Amino-1MQ
NNMT enzyme inhibitor (small molecule)
An orally-active NNMT inhibitor studied for adipocyte metabolism and cellular NAD+ preservation.
How it works
5-Amino-1MQ is a small molecule, not a peptide, studied for its ability to inhibit nicotinamide N-methyltransferase, an enzyme abbreviated NNMT that is highly expressed in fat tissue. Blocking this enzyme raises intracellular levels of NAD+ and SAM, two molecules central to cellular energy metabolism.
This shift in cellular energy currency is proposed to push white adipocytes toward a more metabolically active state, favoring increased lipolysis, the breakdown of stored fat. Because it acts intracellularly on an enzyme rather than a cell surface receptor, its mechanism differs substantially from peptide-based GLP receptor agonists.
Rodent studies report reduced fat mass without changes in diet or activity level, along with improved markers of muscle stem cell function in aged animal models, suggesting an effect that may extend beyond adipose tissue alone.
What research has shown
Rodent studies report reduced fat mass without dietary change and improved muscle stem-cell function in aged models.
Reported ranges in the literature
Low end
50 mg daily (oral)
Optimal
100 to 150 mg daily
High end
250 mg daily
Frequency reported in the literature: Daily, usually morning
Frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ is an orally active small molecule that inhibits the NNMT enzyme, studied for its effects on fat cell metabolism and cellular NAD+ levels.
How does 5-Amino-1MQ differ from GLP-1 receptor agonists?
GLP-1 agonists act on cell surface receptors to reduce appetite and slow gastric emptying. 5-Amino-1MQ works intracellularly by inhibiting an enzyme involved in fat cell energy metabolism, a distinct mechanism.
What does the research show?
Rodent studies report reduced fat mass independent of dietary change, along with improved muscle stem cell function in models of aging.
How is 5-Amino-1MQ typically studied?
Because it is orally bioavailable, published research protocols describe oral daily dosing rather than injection.
How long are research blocks typically?
Available rodent studies generally use continuous daily dosing over several weeks, though standardized human research block lengths are not yet well established.
Related compounds
Further reading
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.