P21
Also known as P021, Ac-DGGLAG-NH2
CNTF-derived neurogenic peptidomimetic
A ciliary neurotrophic factor fragment studied for neurogenesis and reduction of tau pathology in models.
How it works
Mimics the active region of CNTF, stimulating hippocampal neurogenesis and BDNF signaling while inhibiting the leukemia inhibitory factor pathway linked to tau hyperphosphorylation.
What research has shown
Alzheimer model mice show improved memory performance, increased dendritic spine density and reduced tau pathology.
Reported ranges in the literature
Low end
Animal model doses only
Optimal
No established human range
High end
Not characterized in humans
Frequency reported in the literature: Daily in reported animal protocols
Protocol duration and pairing
Typical study duration
2 to 8 weeks in the reported neurogenesis models.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.