Orexin B
Also known as Hypocretin-2
Hypothalamic neuropeptide
The second orexin peptide, selective for OX2R and studied for arousal and feeding circuits.
How it works
Binds OX2R with much higher affinity than OX1R, and OX2R signaling is the arm most closely tied to sleep-wake stabilization in animal models.
What research has shown
Animal work supports its role in arousal and feeding; it has a shorter half-life than Orexin A and less human study.
Reported ranges in the literature
Low end
Study model doses only
Optimal
No established human range
High end
Not characterized
Frequency reported in the literature: Not established
Protocol duration and pairing
Typical study duration
Short exposures, from single administration to 4 weeks.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.