Orexin A
Also known as Hypocretin-1
Hypothalamic wakefulness neuropeptide
A wake-promoting neuropeptide studied for narcolepsy, alertness and appetite regulation.
How it works
Binds OX1R and OX2R receptors to stabilize wakefulness circuits; loss of orexin neurons is the established cause of narcolepsy type 1.
What research has shown
Primate studies report reversal of sleep-deprivation cognitive deficits after intranasal administration; human data is early.
Reported ranges in the literature
Low end
Study model doses only
Optimal
No established human range
High end
Not characterized
Frequency reported in the literature: Morning administration in study protocols
Protocol duration and pairing
Typical study duration
Short exposures, from single administration to 4 weeks.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.