Melanotan II
Non-selective melanocortin receptor agonist
A cyclic alpha-MSH analog studied for melanogenesis and, through MC4R activity, libido and appetite effects.
How it works
Activates MC1R for melanin synthesis and also MC3R and MC4R, which accounts for the appetite suppression and sexual arousal effects reported alongside pigmentation.
What research has shown
Studies report dose-dependent tanning with lower UV exposure, plus MC4R-mediated erectile response, nausea and flushing.
Reported ranges in the literature
Low end
100 mcg daily during loading
Optimal
250 to 500 mcg daily during loading, then 1 to 2 times weekly
High end
1 mg per administration in research reports
Frequency reported in the literature: Daily loading then weekly maintenance in reported protocols. Note: Non-selective receptor activity is why side effects are broader than with Melanotan I.
Protocol duration and pairing
Typical study duration
10 to 30 day loading followed by maintenance.
Best paired with
Shares the melanocortin pathway with PT-141, which is a derivative of it.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.