LL-37
Also known as Cathelicidin LL-37
Human cathelicidin antimicrobial peptide
The only human cathelicidin, studied for antimicrobial defense, biofilm disruption and wound repair.
How it works
Its amphipathic helix inserts into bacterial membranes and disrupts them, while also acting as a chemoattractant for neutrophils, monocytes and T cells.
What research has shown
Wound-healing studies report faster re-epithelialization; in vitro work shows broad activity against bacteria and biofilms.
Reported ranges in the literature
Low end
100 mcg daily
Optimal
100 to 500 mcg daily in research reports
High end
1 mg daily
Frequency reported in the literature: Daily in short blocks. Note: At higher concentrations the literature also reports pro-inflammatory effects.
Protocol duration and pairing
Typical study duration
2 to 8 weeks in the antimicrobial and wound models reported.
Best paired with
Host defense peptide studied with immune modulators and anti-inflammatory peptides.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.