Kisspeptin-10
KISS1R agonist decapeptide
The upstream trigger of GnRH release, studied for reproductive axis signaling and arousal pathways.
How it works
Activates KISS1R on hypothalamic GnRH neurons, which is the physiological switch that initiates a GnRH pulse and downstream LH release.
What research has shown
Human studies report reliable LH increases after administration, plus effects on limbic activity in imaging studies of sexual and emotional processing.
Reported ranges in the literature
Low end
10 mcg per administration
Optimal
50 to 100 mcg per administration
High end
200 mcg in research reports
Frequency reported in the literature: Intermittent, in study blocks
Protocol duration and pairing
Typical study duration
Short studies, often single administration to 4 weeks.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.