Gonadorelin Acetate
Also known as GnRH
Gonadotropin releasing hormone decapeptide
Native GnRH, studied for pulsatile stimulation of LH and FSH release from the pituitary.
How it works
Binds pituitary GnRH receptors and, when delivered in pulses, triggers LH and FSH secretion; continuous exposure instead downregulates the receptor.
What research has shown
Pulsatile administration studies restore gonadotropin output and testicular function in hypogonadotropic cohorts.
Reported ranges in the literature
Low end
100 mcg twice weekly
Optimal
100 mcg every other day in reported protocols
High end
200 mcg daily in short blocks
Frequency reported in the literature: Pulsatile, every 1 to 3 days. Note: The pulsatile pattern matters, since continuous exposure suppresses the axis.
Protocol duration and pairing
Typical study duration
4 to 12 weeks; pulsatile administration is central to the protocols.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.