GDF-8
Also known as Myostatin
TGF-beta family growth factor
Myostatin itself, the negative regulator of muscle mass and the reference ligand for follistatin research.
How it works
Binds ActRIIB receptors and activates SMAD2/3 signaling, which suppresses satellite cell activation and protein synthesis in skeletal muscle.
What research has shown
Loss-of-function mutations in cattle, dogs and humans produce marked muscle hypertrophy, which is why the pathway is a persistent research target.
Reported ranges in the literature
Low end
Assay and reference use only
Optimal
No administration range in the literature
High end
Not applicable
Frequency reported in the literature: Reference standard, not an administered compound. Note: Used as a laboratory reference ligand rather than a research protocol input.
Protocol duration and pairing
Typical study duration
Study durations vary; myostatin models commonly run 4 to 12 weeks.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.