Follistatin
Also known as Follistatin-344
Activin and myostatin binding glycoprotein
A natural myostatin antagonist studied for muscle mass regulation in gene-transfer and protein models.
How it works
Binds and neutralizes myostatin and activin A, removing the brake those ligands place on muscle satellite cell proliferation and protein accretion.
What research has shown
Gene-transfer studies in primates and mice report substantial increases in muscle mass; protein-administration human data is not published.
Reported ranges in the literature
Low end
50 mcg daily in research reports
Optimal
100 mcg daily in short blocks
High end
200 mcg daily
Frequency reported in the literature: Daily in 10 to 30 day blocks in reported protocols. Note: Human evidence is very limited compared with animal gene-transfer work.
Protocol duration and pairing
Typical study duration
10 to 30 day blocks in the reported animal work.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.