AICAR
Also known as Acadesine
AMPK activator (nucleoside analog)
A nucleoside analog studied as a direct exercise-mimetic through AMP-activated protein kinase signaling.
How it works
Converts intracellularly to ZMP, which mimics AMP and activates AMPK, shifting cells toward fatty-acid oxidation, glucose uptake and mitochondrial biogenesis.
What research has shown
Rodent studies reported increased running endurance without training; human work has focused on ischemia protection rather than performance.
Reported ranges in the literature
Low end
10 mg/kg daily in animal studies
Optimal
250 to 500 mg daily in reported research protocols
High end
500 mg daily, the upper figure cited in research reports
Frequency reported in the literature: Daily during study blocks
Protocol duration and pairing
Typical study duration
2 to 8 weeks in the exercise mimetic literature.
Best paired with
AMPK activation overlaps with the ERR pathway that SLU-PP-332 targets.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.