MK-677
Also known as Ibutamoren
Orally active ghrelin receptor agonist
A non-peptide secretagogue studied for sustained 24-hour elevation of GH and IGF-1 with oral bioavailability.
How it works
Binds GHS-R1a with a long half-life, raising both GH pulse amplitude and baseline, and increasing IGF-1 for the full dosing interval.
What research has shown
Trials report IGF-1 increases of 40 to 90%, increased fat-free mass, and dose-related increases in appetite, fluid retention and fasting glucose.
Reported ranges in the literature
Low end
10 mg daily
Optimal
12.5 to 25 mg daily
High end
25 mg daily, the common ceiling in trial data
Frequency reported in the literature: Once daily, usually evening. Note: Glucose and insulin sensitivity changes are documented at higher exposures.
Protocol duration and pairing
Typical study duration
8 weeks to 24 months across the published literature.
Best paired with
Oral ghrelin mimetic that raises IGF-1 continuously rather than in pulses.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.