Vitamin B-12
Also known as Cyanocobalamin, methylcobalamin
Cobalamin micronutrient
A cofactor vitamin supplied as solution or lyophilized powder, used in energy metabolism research contexts.
How it works
Serves as a cofactor for methionine synthase and methylmalonyl-CoA mutase, both required for one-carbon metabolism and mitochondrial substrate handling.
What research has shown
Correction of deficiency reliably improves hematologic and neurologic markers; benefits in replete subjects are not well supported.
Reported ranges in the literature
Low end
250 mcg weekly
Optimal
1000 mcg weekly
High end
1000 mcg two to three times weekly in deficiency protocols
Frequency reported in the literature: Weekly in most protocols
Protocol duration and pairing
Typical study duration
4 to 12 weeks in repletion studies.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.