Adipotide
Also known as FTPP, prohibitin-targeting peptide
Proapoptotic peptidomimetic
An experimental compound studied for targeted reduction of white adipose tissue through vascular pruning.
How it works
Homes to prohibitin on the blood vessels that supply white fat and triggers apoptosis in those endothelial cells, cutting the blood supply to the fat depot.
What research has shown
Primate studies reported roughly 11% body weight reduction over 4 weeks, with renal effects that halted further development.
Reported ranges in the literature
Low end
0.1 mg/kg daily in animal work
Optimal
0.43 mg/kg daily, the primate study dose
High end
Higher exposures were associated with renal toxicity in animals
Frequency reported in the literature: Daily in reported animal protocols. Note: Animal data only. Renal findings are the dominant safety signal in the literature.
Protocol duration and pairing
Typical study duration
Preclinical work uses short 4 week cycles because of renal findings.
Best paired with
Not paired with other compounds in the available literature; renal safety signals dominate the record.
Research use only
All content on this page is general reference information for laboratory research contexts. It is not medical advice, is not intended to direct human use, and does not replace guidance from a licensed healthcare professional. Not for human consumption. Must be 18+.